OVARIAN CANCER

Epithelial ovarian cancer in the United States is a relatively rare in Gynecologic Oncology, 2004, there were approximately 25,580 cases of new onset patients, 16,090 cases patients died. The majority of patients with advanced cancer, treatment for surgical resection and postoperative to platinum-based chemotherapy. During the past 10 years, chemotherapy improved survival rates improve, and recurrent tumor treatment more effective. In addition, the genetic risk factors for making in-depth understanding of the prevention strategy to become individualized approach to bilateral tubal women - ovarian surgery. This report summarized the clinical characteristics of epithelial ovarian, after reports focus on the treatment of the latest developments.

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I. Overview

With the aging of the global trend of development, improve the economic status of women, more and more women start hormone replacement therapy (Hormone Replacement Therapy, HRT), to improve access to after menopause due to the decrease in the level of sex hormones related to various diseases. Clear evidence that: postmenopausal women with age, the incidence of coronary heart disease increased by about four times the fracture due to osteoporosis by 20%, died of complications due to pelvic fracture rate of 30%, after the 65-year-old Alzheimer's incidence rate increase every year <BR> and Application HRT can peer groups coronary heart disease risk 50% Alzheimer's risk reduced three times, especially worth mentioning is significantly reduced the incidence of rectal cancer. Long-term use of HRT cancer risk reduced year by year. HRT can also greatly improve the menopause, postmenopausal women with disease or ovarian surgery, radiotherapy in patients with a series of artificial menopause syndrome.

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Cytoreductive surgery in the treatment of ovarian cancer Comprehensive Application and prospects

Foreign Medical Obstetrics and Gynecology volumes in 1999 Vol 26 No. 2

Tianjin Medical University General Hospital of Obstetrics and Gynecology (300,052) of the new QU (Summary) if Mi (revision)

Abstract <BR> since the 1980s, complete cytoreductive surgery to cisplatin-based combination chemotherapy for ovarian cancer as a conventional model, cytoreductive surgery is the complete impact of the prognosis of patients with one of the important factors for recurrent ovarian cancer once again cytoreductive surgery still some value , but to improve the survival rate of patients is more important to be effective after chemotherapy treatment as a necessary complement. Early ovarian cancer retroperitoneal lymph node dissection is reasonable and significance of the still controversial.

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Swedish experts recently warned that, for those with breast or ovarian cancer family history of the young women, if they have been diagnosed with breast cancer, then their risk of ovarian cancer risk would be significantly increased by 10 times. So even the experts recommended that certain breast cancer patients may be necessary for the prevention of suffering from such as ovarian cancer
Preventive measures. Kjell Bergfeldt Karolinska Institute, Doctor of Medicine, in its study of more than 30,000 cases compared 70 patients with breast cancer under the age of the medical records, and also whether their immediate family members with breast cancer or ovarian cancer cases were investigated. The results showed that if their mothers, sisters or daughters of people with breast cancer or ovarian cancer, who before the age of 40 was diagnosed with breast cancer before the age of 70 women with ovarian cancer risk will increase six-fold and 17-fold. Relevant experts believe that the discovery confirmed the existence of two types of cancer among some related links. Previous studies have already noted, carrying the BRCA1 or BRCA2 gene mutations in breast cancer patients with about 40% of people will be suffering from ovarian cancer.

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Abstract: a group P53 mutations in the genes in patients with advanced ovarian cancer by more cycles of P53 gene therapy and chemotherapy, reducing disease, the survival rate has improved. (The Fourth Annual Gene Therapy & Molecular Biology Conference, Rhodes, Greece)

American University of Iowa Dr. Richard Buller reported they received early treatment to strengthen the 36 patients with advanced ovarian cancer to the adenovirus vector into the peritoneal tumor suppressor gene p53 function of the combination of chemotherapy I / II clinical trials of the preliminary results. The results show that several gene therapy / chemotherapy combination therapy in patients with an average survival of 14.8. Nine people have survived 19.5 months, are still alive. The survival rate is higher than five separate gene therapy on the survival rate is also higher than the average with paclitaxel (Taxol) in the treatment of recurrent ovarian cancer new 15-month survival rate.

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Usually that cervical cancer is a certain type of human papilloma virus (HPV) caused. Now Johns Hopkins University researchers think that some head and neck cancer, particularly tongue and tonsil cancer with the following regional HPV infection. They also found that HPV-positive head and neck cancer prognosis, the other with head and neck cancer different.

V. said Dr. Keerti Shah, head and neck cancer usually is not a good prognosis, in the majority of patients the disease is advanced only found. However, HPV-positive cancer under the microscope is obvious characteristics, so pathologists can immediately determine whether the HPV-positive tumors.

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Fear is of aliasing, busy with work and career, the duo has just world, "DINK family" for refusing to identify a wide range of reproductive excuse. However, you decide to do DINK family, the doctor may listen to the following advice and recommendations: no fertility of women, the incidence of ovarian cancer than women with a history of fertility; If there is a complete female breeding process can be enhanced to prevent ovarian cancer, breast cancer and gynecological cancer immunity.

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For a long time, ovarian cancer is malignant gynecologic tumors in the highest degree. In the United States, the mortality rate since 1979 as medical research has not progressed any lower, always maintained at about 9.8 per 100,000.

Currently known ovarian cancer in a related gene p53 gene. The human gene that regulates the transcription of certain genes, thereby inhibiting cell proliferation and repair damage cells. The function of this gene defect could lead to abnormal cell proliferation occurring.

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Henan Medical University, a professor of obstetrics and gynecology buildings Qiao Yu, graduate students and others Rui - Xia Guo recent study found that in some tumor suppressor gene amplification or overexpression of ovarian cancer is the key factor. Entitled "epithelial ovarian cancer tumor mechanism and clinical application of" scientific research, recently Henan "progress of science and technology second prize."

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【Medical industry network was HealthScoutNews August 28, 2002 - 40 years before being diagnosed with breast cancer in women if the family history of cancer or ovarian cancer, with more risk of ovarian cancer than those without family history. Sweden also show that the conclusion of the study: high-risk women should closely follow-up counseling, and to consider the removal of ovarian prevention. See today's "Lancet" (The Lancet) magazine Web content.

Tags: age, brca1, breast, cancer, cause, children, diagnosis, early, ert, family, gene, history, increased, method, mutation, ovarian, patients, preventive, risk, study, time, women