OVARIAN CANCER

One, paclitaxel and cisplatin in the treatment of advanced ovarian cancer care <BR> <BR> 1990s Taxol is more of the treatment of advanced ovarian cancer drug effective, and its unique mechanism is a new type of anti-tubulin role of antitumor drugs. Cisplatin for inorganic platinum metal complex, the cell cycle-specific drug, can inhibit DNA synthesis, combined with their synergies to enhance the effectiveness of [1]. In Division I from July 1996 to July 1998 to 15 cases of advanced ovarian cancer patients with Taxol and cisplatin in the treatment of satisfactory results.

One, information and Methods

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I. Overview

With the aging of the global trend of development, improve the economic status of women, more and more women start hormone replacement therapy (Hormone Replacement Therapy, HRT), to improve access to after menopause due to the decrease in the level of sex hormones related to various diseases. Clear evidence that: postmenopausal women with age, the incidence of coronary heart disease increased by about four times the fracture due to osteoporosis by 20%, died of complications due to pelvic fracture rate of 30%, after the 65-year-old Alzheimer's incidence rate increase every year <BR> and Application HRT can peer groups coronary heart disease risk 50% Alzheimer's risk reduced three times, especially worth mentioning is significantly reduced the incidence of rectal cancer. Long-term use of HRT cancer risk reduced year by year. HRT can also greatly improve the menopause, postmenopausal women with disease or ovarian surgery, radiotherapy in patients with a series of artificial menopause syndrome.

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Cytoreductive surgery in the treatment of ovarian cancer Comprehensive Application and prospects

Foreign Medical Obstetrics and Gynecology volumes in 1999 Vol 26 No. 2

Tianjin Medical University General Hospital of Obstetrics and Gynecology (300,052) of the new QU (Summary) if Mi (revision)

Abstract <BR> since the 1980s, complete cytoreductive surgery to cisplatin-based combination chemotherapy for ovarian cancer as a conventional model, cytoreductive surgery is the complete impact of the prognosis of patients with one of the important factors for recurrent ovarian cancer once again cytoreductive surgery still some value , but to improve the survival rate of patients is more important to be effective after chemotherapy treatment as a necessary complement. Early ovarian cancer retroperitoneal lymph node dissection is reasonable and significance of the still controversial.

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Ovarian cancer mortality first Habitat gynecologic malignancies, as misprision of onset, 70% of patients when treatment is already advanced. Surgery and chemotherapy comprehensive application is the treatment of advanced ovarian cancer, especially epithelial ovarian cancer therapy of choice. Platinum drug resistance ovarian cancer is the main reason for treatment failure. To solve this problem, clinical oncologist to a variety of solutions, is chosen in 2003 after the open literature on the following:

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[Summary]

Ovarian cancer is a common cancer of female genital mutilation one of the incidence of cervical cancer and after cancer of the uterus, which ranked third. But ovarian cancer death, accounts of the first gynecologic tumors, right pose a serious threat to women's lives. Because ovarian embryonic development, organization anatomy and endocrine function more complicated, it may be suffering from benign tumors or malignant. Because of early ovarian cancer in asymptomatic, and the identification of its type benign and malignant very difficult, ovarian carcinoma laparotomy in ovarian tumor confined to only 30%, most have spread to the uterus, bilateral annex, the omentum and pelvic organs, both in the diagnosis of ovarian cancer and governance the treatment is a major problem indeed. Over the years experts on the pathological form of ovarian cancer, the development of clinical and treatment programs for many of accumulated a lot of experience, so far, statistics on domestic and foreign clinical data, the five-year survival rate of only 25% to 30%.

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Common and prognosis factors:

• clinical stage and is closely related to survival;

• histological type and grade pathology and prognosis is directly related;

• differentiation and biological characteristics and the prognosis also directly related to a direct impact on the survival rate and survival time.

• In addition, the age factor and the prognosis of more closely. Another treatment option with a reasonable and thorough, but also directly affect the prognosis of ovarian cancer.

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Abstract: Application of transvaginal ultrasound contrast with early ovarian cancer screening with a simple standard, the advantages of the Express. (Cancer 2000; 89:582-587)

According to the Japanese study published in the August 1 published in the Journal of Cancer Cancer), a research report said they Application of transvaginal ultrasound contrast (transvaginal EUS.Silver, TVS) screening early ovarian cancer. Hirosaki University School of Medicine, Dr. Sato and his colleagues at TVS to 183,034 cases of asymptomatic women for as long as 10 follow-up inspection. These patients have participated in cervical cancer screenings, and just completed a two-minute inspection. In these women, 51,550 women were screened for the first time the census.

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Breast cancer screening time <BR> <BR> that breast cancer screening, women will think about breast self-examination. To promote breast self-examination has some significance to the advancement of women on the importance of breast health. But if not taught women how to correctly implemented, it is very dangerous. The American Cancer Medicine will not touch themselves, worries that if women should consult their doctors. Many studies have found that women can correct implementation of breast self-examination rate is not high, the United States is only about 32%.

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Ovarian cancer is prone than Caucasian Europe and the United States, but recently the Taiwan people with the risk of ovarian cancer is also gradually increasing its greatest danger is early diagnosis difficult, in addition to using ultrasound, CT, even tumor marker CA-125 is very difficult to predict from, although tumor marker right up inspection Broken disease not help, but CA-125 in assessing treatment efficacy rather than tomography or ultrasound also accurate.
This is in Copenhagen, Denmark Gronlund's research team recently proposed to the report, 68 of ovarian cancer patients, topotecan plus carboplatin or paclitaxel in ovarian cancer with chemotherapy on the second line, tomography, ultrasound, or serum CA-125 concentration to assess the efficacy of chemotherapy results found that CA-125 concentrations than expensive tomography or complex sonography in predicting survival, 2.6 times more accuracy.

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Ovarian cancer early detection difficult until the inspection was coming out of the general cancer has spread, treatment too late. Researchers in the United States recently reported that they found a blood-screening early detection of ovarian cancer and new ways to its accuracy rate of 95%.
American scientists in experiments, the researchers examined 86 women of 169 proteins in the blood levels. These women were 28 healthy women, 58 were patients with ovarian cancer. From the experiments are Leptin, Lactagogue hormone, osteopontin and insulin-like growth factor, the four protein level model, the researchers further <BR> done a greater scale experiments to be verified, come to the conclusion that if the four protein content dropped to within a certain range , can be diagnosed with ovarian cancer.

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