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In Orlando at the American Association for Cancer Research annual meeting, Philadelphia's Fox Chase Cancer Center researchers proposed a new research results, analgesic drugs such as aspirin, ibuprofen, Celebrex and Vioxx could help prevent ovarian cancer, these common anti-inflammatory drugs could inhibit cox 2 enzyme, may be able to slow the rapid ovarian cell changes, and can reduce the formation of malignant cells potential risks.

The study leader Xiang-Xi (Mike) Xu said that the cox-2 enzyme have a role in the process is unusual mechanism. When we released the report, it is obvious that this truth, but before this mechanism was not found.

Relatively speaking, ovarian cancer is rare, but a high mortality rate, because ovarian tumor was found not usually until the cancer has spread to other organs, was not found. For the United States in terms of women, ovarian cancer has become the fifth-largest cancer killer, every year some 15,000 people have been killed lives.

In this study, researchers focused on the initial ovarian tumor in what position. Dr. Xu explained that 90% of cancers, including ovarian cancer, and from the organizations that the surface layer of cells epithelial cells, which in a collagen "net" - the basement membrane, with up to a 1. When laboratory analysis of ovarian epithelial cells, the researchers found that overexpression of cox-2 enzyme would seriously damage the membrane. Damage to the basement membrane of epithelial cells will have a negative impact on the life cycle, or variation will accelerate the accumulation of precursor cells, increasing the risk of cancer.

People now know that cox-2 can cause inflammation reaction, but also indirectly lead to headache or joint pain. Non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen can block cox-1 and cox-2 enzymes, while the new arthritis drugs Celebrex and Vioxx only by reducing the cox-2 to alleviate pain (cox-1 enzyme also protects the stomach endometrial because Celebrex Vioxx, and not inhibit it, as was the treatment of gastrointestinal diseases, prescription drugs).

The Food and Drug Administration has approved the drug as a colon cancer prevention drug, some studies have suggested that these drugs can help women reduce the risk of breast cancer.

Dr. Xu, cox-2 inhibitors can reduce the damage of the basement membrane, to help prevent ovarian cancer. In addition to eliminating inflammation, cox-2 in our body also has other functions, including stimulate ovulation. When ovulation, the basement membrane will be removed, now that a number of women ovulate more, she suffering from ovarian cancer, the greater the risk. Of course, women in their lifetime due to pregnancy, breast-feeding or taking birth control drugs may reduce the risk of ovarian cancer.

Dr. Xu said that, in general, any activity to reduce the cox-2 drugs would reduce the risk of ovarian cancer.

The American Cancer Society director of breast and gynecological cancers, said Debbie Saslow, the findings provide an ovarian tumor mechanism of the "new information", but the study is still in the basic research stage.

Meanwhile, the research group plans to conduct a study on the basis of population, the main consideration for the family history of ovarian cancer in high-risk women in their ovarian tissues change the situation. Researchers collected, and those who did not take non-steroidal anti-inflammatory drugs female tissue. Dr. Xu said, by comparison, we should first study whether there are any ovarian organizational change.

Saslow said that the variety of technologies are waiting for the U.S. Food and Drug Administration approval process. Each has been approved effective detection and it is too early, there is also a lot of important things.

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