P53 gene can cure ovarian cancer

P53 gene can affect ovarian cancer prognosis For a long time, ovarian cancer is malignant gynecologic tumors in the highest degree. In the United States, the mortality rate since 1979 a...

British scientists find anti-female ovarian cancer gene British "Nature Genetics" recently published text, British scientists have found a gene named OPCML. 90% of women suffering from...

Abstract: a group P53 mutations in the genes in patients with advanced ovarian cancer by more cycles of P53 gene therapy and chemotherapy, reducing disease, the survival rate has improved. (The Fourth Annual Gene Therapy & Molecular Biology Conference, Rhodes, Greece)

American University of Iowa Dr. Richard Buller reported they received early treatment to strengthen the 36 patients with advanced ovarian cancer to the adenovirus vector into the peritoneal tumor suppressor gene p53 function of the combination of chemotherapy I / II clinical trials of the preliminary results. The results show that several gene therapy / chemotherapy combination therapy in patients with an average survival of 14.8. Nine people have survived 19.5 months, are still alive. The survival rate is higher than five separate gene therapy on the survival rate is also higher than the average with paclitaxel (Taxol) in the treatment of recurrent ovarian cancer new 15-month survival rate.

Buller said that the combination of chemotherapy treatment and gene therapy of synergies. Completed three of the patients showed that 44% of in vivo tumor marker CA125 reduced more than 50%. Buller that ovarian cancer is very suitable for gene therapy because even with advanced performance, in general, limited to the transfer of intraperitoneal.

They recently started a large-scale random P53 gene therapy Phase III clinical, patients will receive carboplatin (Carboplatin) and paclitaxel (Taxol) or carboplatin, paclitaxel and P53 gene therapy.

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Ovarian cancer can also early detection

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Tags: age, cancer, carboplatin, cause, chemotherapy, clinical, early, eat, gene, group, intraperitoneal, mutation, ovarian, p53, paclitaxel, patients, rate, reduce, survival, taxol, therapy, treatment, tumor

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